Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases

Biosensors (Basel). 2022 Dec 16;12(12):1176. doi: 10.3390/bios12121176.

Abstract

Among the most critical health issues, brain illnesses, such as neurodegenerative conditions and tumors, lower quality of life and have a significant economic impact. Implantable technology and nano-drug carriers have enormous promise for cerebral brain activity sensing and regulated therapeutic application in the treatment and detection of brain illnesses. Flexible materials are chosen for implantable devices because they help reduce biomechanical mismatch between the implanted device and brain tissue. Additionally, implanted biodegradable devices might lessen any autoimmune negative effects. The onerous subsequent operation for removing the implanted device is further lessened with biodegradability. This review expands on current developments in diagnostic technologies such as magnetic resonance imaging, computed tomography, mass spectroscopy, infrared spectroscopy, angiography, and electroencephalogram while providing an overview of prevalent brain diseases. As far as we are aware, there hasn't been a single review article that addresses all the prevalent brain illnesses. The reviewer also looks into the prospects for the future and offers suggestions for the direction of future developments in the treatment of brain diseases.

Keywords: Alzheimer; bioprinting; brain tumor; machine learning; nanocarriers; tomography; wearables.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain Diseases* / diagnosis
  • Brain Diseases* / pathology
  • Brain Diseases* / therapy
  • Drug Carriers
  • Humans
  • Quality of Life
  • Wearable Electronic Devices*

Substances

  • Drug Carriers

Grants and funding

B.R. acknowledges A-STAR-SINGA (SING-2021-02-0819), offered by Agency for Science, Technology and Research (A*STAR) Singapore.