Recent Advances in Nanotechnology for the Management of Klebsiella pneumoniae-Related Infections

Mahmood Barani; Hadis Fathizadeh; Hassan Arkaban; Davood Kalantar-Neyestanaki; Majid Reza Akbarizadeh; Abduladheem Turki Jalil; Reza Akhavan-Sigari

doi:10.3390/bios12121155

Recent Advances in Nanotechnology for the Management of Klebsiella pneumoniae-Related Infections

Biosensors (Basel). 2022 Dec 10;12(12):1155. doi: 10.3390/bios12121155.

Authors

Mahmood Barani^{1

2}, Hadis Fathizadeh³, Hassan Arkaban⁴, Davood Kalantar-Neyestanaki^{2

5}, Majid Reza Akbarizadeh⁶, Abduladheem Turki Jalil⁷, Reza Akhavan-Sigari^{8

9}

Affiliations

¹ Student Research Committee, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
² Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
³ Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan 7616916338, Iran.
⁴ Department of Chemistry, University of Isfahan, Isfahan 8174673441, Iran.
⁵ Department of Medical Microbiology (Bacteriology and Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
⁶ Department of Pediatric, Amir Al Momenin Hospital, Zabol University of Medical Sciences, Zabol 9861663335, Iran.
⁷ Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, Iraq.
⁸ Department of Neurosurgery, University Medical Center Tuebingen, 72076 Tuebingen, Germany.
⁹ Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University, 00014 Warsaw, Poland.

Abstract

Klebsiella pneumoniae is an important human pathogen that causes diseases such as urinary tract infections, pneumonia, bloodstream infections, bacteremia, and sepsis. The rise of multidrug-resistant strains has severely limited the available treatments for K. pneumoniae infections. On the other hand, K. pneumoniae activity (and related infections) urgently requires improved management strategies. A growing number of medical applications are using nanotechnology, which uses materials with atomic or molecular dimensions, to diagnose, eliminate, or reduce the activity of different infections. In this review, we start with the traditional treatment and detection method for K. pneumoniae and then concentrate on selected studies (2015-2022) that investigated the application of nanoparticles separately and in combination with other techniques against K. pneumoniae.

Keywords: Klebsiella pneumoniae; antibacterial; detection; metallic nanoparticles; nanotechnology.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Humans
Klebsiella pneumoniae*
Nanotechnology
Urinary Tract Infections*

Substances

Anti-Bacterial Agents

Grants and funding

This article is the result of the research project approved by the student research committee of Kerman University of Medical Sciences under the number 400001085, which was carried out with the financial support of the Research and Technology Vice-Chancellor of this university.