Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease

Sabya Sachi Das; Niraj Kumar Jha; Saurabh Kumar Jha; Priya Ranjan Prasad Verma; Ghulam Md Ashraf; Sandeep Kumar Singh

doi:10.2174/1570159X21666221221092250

Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson's Disease

Curr Neuropharmacol. 2023;21(7):1464-1466. doi: 10.2174/1570159X21666221221092250.

Authors

Sabya Sachi Das^{1

2}, Niraj Kumar Jha^{3

4

5}, Saurabh Kumar Jha^{3

4

6}, Priya Ranjan Prasad Verma¹, Ghulam Md Ashraf⁷, Sandeep Kumar Singh¹

Affiliations

¹ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
² School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun, 248009, Uttarakhand, India.
³ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, 201310, Uttarpradesh, India.
⁴ Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India.
⁵ School of Bioengineering & Biosciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
⁶ Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, Punjab, India.
⁷ Department of Medical Laboratory Sciences, College of Health Sciences, and Sharjah Institute for Medical Research, University of Sharjah, Sharjah, 27272, United Arab Emirates.

Abstract

Quercetin, a natural antioxidant, exhibits potential neuroprotective effects by efficiently downregulating α-synuclein protein aggregation and associated neurological hallmarks, responsible for the progression of Parkinson's Disease.

Keywords: Parkinson’s disease; Quercetin; antioxidant; neuroprotective effects; α -synuclein protein; α -synuclein-associated molecular hallmarks.

Publication types

Editorial

MeSH terms

Humans
Neuroprotective Agents* / pharmacology
Neuroprotective Agents* / therapeutic use
Parkinson Disease* / drug therapy
Parkinson Disease* / metabolism
Quercetin / pharmacology
Quercetin / therapeutic use
alpha-Synuclein / metabolism

Substances

alpha-Synuclein
Quercetin
Neuroprotective Agents