DJ-1 promotes cell migration by interacting with Mena, the mammalian homolog of Drosophila enabled

Adv Biol Regul. 2023 May:88:100943. doi: 10.1016/j.jbior.2022.100943. Epub 2022 Dec 16.

Abstract

DJ-1 has gained extensive attention after being identified in 2003 as a protein implicated in the pathogenesis of early-onset Parkinson's disease. Since then, efforts have revealed versatile DJ-1 functions in reactive oxygen species (ROS) control, transcriptional regulation, chaperone function, fertility, and cell transformation. Herein, we report a novel function of DJ-1 in actin cytoskeletal rearrangements. DJ-1 was identified as a new binding partner of Mena, a protein of the Enah/VASP family, and it promoted cancer cell migration by Mena-dependent actin polymerization and filopodia formation. These results suggest a novel molecular mechanism for DJ-1-dependent cancer cell invasion and metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins* / chemistry
  • Animals
  • Cell Movement
  • Cytoskeleton
  • Drosophila / genetics
  • Drosophila / metabolism
  • Mammals / metabolism
  • Microfilament Proteins* / genetics
  • Microfilament Proteins* / metabolism
  • Protein Deglycase DJ-1* / chemistry
  • Protein Deglycase DJ-1* / metabolism

Substances

  • Actins
  • Microfilament Proteins
  • Protein Deglycase DJ-1
  • Enah protein, mouse