Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Yi Ju; Juan Manuel Carreño; Viviana Simon; Kenneth Dawson; Florian Krammer; Stephen J Kent

doi:10.1038/s41577-022-00825-x

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Nat Rev Immunol. 2023 Mar;23(3):135-136. doi: 10.1038/s41577-022-00825-x.

Authors

Yi Ju^#^{1

2}, Juan Manuel Carreño^#^{3

4}, Viviana Simon^{3

4

5

6

7}, Kenneth Dawson⁸, Florian Krammer^{9

10

11}, Stephen J Kent^{12

13}

Affiliations

¹ Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.
² School of Science and School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
³ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁵ Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁶ Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁷ Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁸ Centre for BioNano Interactions, School of Chemistry, University College Dublin, Dublin, Ireland.
⁹ Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.
¹⁰ Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.
¹¹ Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. florian.krammer@mssm.edu.
¹² Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia. skent@unimelb.edu.au.
¹³ Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia. skent@unimelb.edu.au.

^# Contributed equally.

Abstract

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.

MeSH terms

Antibodies, Neutralizing
COVID-19 Vaccines
COVID-19*
Humans
SARS-CoV-2
Vaccines, Synthetic

Substances

COVID-19 Vaccines
Vaccines, Synthetic
Antibodies, Neutralizing