Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Tengfei Liu; Yifei Lu; Rixing Zhan; Wei Qian; Gaoxing Luo

doi:10.1016/j.addr.2022.114670

Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Adv Drug Deliv Rev. 2023 Feb:193:114670. doi: 10.1016/j.addr.2022.114670. Epub 2022 Dec 17.

Authors

Tengfei Liu¹, Yifei Lu¹, Rixing Zhan¹, Wei Qian¹, Gaoxing Luo²

Affiliations

¹ Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University (Third Military Medical University), Chongqing 400038, China.
² Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University (Third Military Medical University), Chongqing 400038, China. Electronic address: gaoxing.luo@burnstrauma.com.

PMID: 36538990
DOI: 10.1016/j.addr.2022.114670

Abstract

Various factors could damage the structure and integrity of skin to cause wounds. Nonhealing or chronic wounds seriously affect the well-being of patients and bring heavy burdens to the society. The past few decades have witnessed application of numerous nanomaterials to promote wound healing. Owing to the unique physicochemical characteristics at nanoscale, nanomaterials-based therapy has been regarded as a potential approach to promote wound healing. In this review, we first overview the wound categories, wound healing process and critical influencing factors. Then applications of nanomaterials with intrinsic therapeutic effect and nanomaterials-based drug delivery systems to promote wound healing are addressed in detail. Finally, current limitations and future perspectives of nanomaterials in wound healing are discussed.

Keywords: Chronic wounds; Drug delivery; Nanomaterial; Nanomedicine; Wound healing.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems
Humans
Nanostructures* / chemistry
Skin
Wound Healing*