Long-term effect of photodynamic therapy on oral squamous cell carcinoma and epithelial dysplasia

Shun Narahara; Hisazumi Ikeda; Kinuko Ogata; Rena Shido; Izumi Asahina; Seigo Ohba

doi:10.1016/j.pdpdt.2022.103246

Long-term effect of photodynamic therapy on oral squamous cell carcinoma and epithelial dysplasia

Photodiagnosis Photodyn Ther. 2023 Mar:41:103246. doi: 10.1016/j.pdpdt.2022.103246. Epub 2022 Dec 16.

Authors

Shun Narahara¹, Hisazumi Ikeda², Kinuko Ogata¹, Rena Shido¹, Izumi Asahina³, Seigo Ohba⁴

Affiliations

¹ Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Japan.
² Unit of Dentistry, Sasebo City General Hospital, Japan.
³ Department of Oral and Maxillofacial Surgery, Juntendo University Hospital, Japan.
⁴ Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Japan. Electronic address: seigoohba@gmail.com.

PMID: 36535598
DOI: 10.1016/j.pdpdt.2022.103246

Abstract

Background: Oral squamous cell carcinoma (OSCC) treatment consists mainly of surgery, chemotherapy, and radiotherapy, alone or in combination. Epithelial dysplasia (ED) is also treated with surgery. However, these treatments can induce functional and/or aesthetic disturbances. Photodynamic therapy (PDT) can preserve organs. Although short-term studies have shown good progress, long-term evaluations have not yet been conducted. This study aimed to clarify the long-term effects of PDT on OSCC and ED.

Methods: Patients who underwent PDT with the first (porfimer sodium) or second generation photosensitizers (talaporfin sodium) for early OSCC (T1 and T2) and ED were included in this study. The long-term prognosis was assessed.

Results: Twenty-three patients were included. Complete response (CR) was observed in 19 patients (82.6%) and partial response (PR) in 4 patients (17.4%) 4 weeks after PDT. Regarding long-term progress, local region recurrence occurred in 11 of 19 CR cases (57.9%), and the term of recurrence was 27.4 ± 30.4 months. Surgical resection was performed in all local recurrence and PR cases, and 3 patients died of the underlying disease.

Conclusions: PDT provides a good outcome in the short term, but its long-term effects are limited.

Keywords: Epithelium dysplasia (ED); Oral squamous cell carcinoma (OSCC); Photodynamic therapy (PDT).

MeSH terms

Carcinoma in Situ* / drug therapy
Carcinoma, Squamous Cell* / pathology
Head and Neck Neoplasms* / drug therapy
Humans
Mouth Neoplasms* / drug therapy
Mouth Neoplasms* / pathology
Neoplasm Recurrence, Local / drug therapy
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
Squamous Cell Carcinoma of Head and Neck / drug therapy
Treatment Outcome

Substances

Photosensitizing Agents