Natural products against inflammation and atherosclerosis: Targeting on gut microbiota

Bing Deng; Liyu Tao; Yiru Wang

doi:10.3389/fmicb.2022.997056

Natural products against inflammation and atherosclerosis: Targeting on gut microbiota

Front Microbiol. 2022 Dec 1:13:997056. doi: 10.3389/fmicb.2022.997056. eCollection 2022.

Authors

Bing Deng¹, Liyu Tao², Yiru Wang¹

Affiliations

¹ Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

The gut microbiota (GM) has become recognized as a crucial element in preserving human fitness and influencing disease consequences. Commensal and pathogenic gut microorganisms are correlated with pathological progress in atherosclerosis (AS). GM may thus be a promising therapeutic target for AS. Natural products with cardioprotective qualities might improve the inflammation of AS by modulating the GM ecosystem, opening new avenues for researches and therapies. However, it is unclear what components of natural products are useful and what the actual mechanisms are. In this review, we have summarized the natural products relieving inflammation of AS by regulating the GM balance and active metabolites produced by GM.

Keywords: atherosclerosis; gut microbiota; immune; inflammation; natural products.

Publication types

Review