The role of microfibrillar-associated protein 2 in cancer

Wanzhen Xu; Manfeng Wang; Yang Bai; Yong Chen; Xiaoshan Ma; Zhiqing Yang; Liyan Zhao; Yunqian Li

doi:10.3389/fonc.2022.1002036

The role of microfibrillar-associated protein 2 in cancer

Front Oncol. 2022 Nov 30:12:1002036. doi: 10.3389/fonc.2022.1002036. eCollection 2022.

Authors

Wanzhen Xu¹, Manfeng Wang², Yang Bai¹, Yong Chen¹, Xiaoshan Ma¹, Zhiqing Yang³, Liyan Zhao⁴, Yunqian Li¹

Affiliations

¹ Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.
² Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
³ Department of Emergency Medicine, Binzhou People's Hospital, Binzhou, China.
⁴ Department of Clinical Laboratory, Second Hospital of Jilin University, Changchun, China.

Abstract

Microfibrillar-associated protein 2 (MFAP2), a component of the extracellular matrix, is important in controlling growth factor signal transduction. Recent studies have shown that MFAP2, an effective prognostic molecule for various tumors, is associated with tumor occurrence and development and may be involved in remodeling the extracellular matrix and regulating proliferation, apoptosis, invasion, tumor cell metastasis, and tumor angiogenesis. However, MFAP2's specific mechanism in these tumor processes remains unclear. This article reviewed the possible mechanism of MFAP2 in tumorigenesis and progression and provided a reference for the clinical prognosis of patients with cancer and new therapeutic target discovery.

Keywords: MFAP2; angiogenesis; apoptosis; extracellular matrix (ECM); invasion; metastasis; prognosis; proliferation.

Publication types

Review