Radiation-assisted strategies provide new perspectives to improve the nanoparticle delivery to tumor

Dongxiao Zhang; Jian He; Min Zhou

doi:10.1016/j.addr.2022.114642

Radiation-assisted strategies provide new perspectives to improve the nanoparticle delivery to tumor

Adv Drug Deliv Rev. 2023 Feb:193:114642. doi: 10.1016/j.addr.2022.114642. Epub 2022 Dec 15.

Authors

Dongxiao Zhang¹, Jian He², Min Zhou³

Affiliations

¹ Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China.
² The Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China.
³ Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining 314400, China; The Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China; Cancer Center, Zhejiang University, Hangzhou 310058, China; Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Hangzhou 310053, China. Electronic address: zhoum@zju.edu.cn.

PMID: 36529190
DOI: 10.1016/j.addr.2022.114642

Abstract

Nanoparticles (NPs), with advantages in tumor targeting, have been extensively developed for anticancer treatment. However, the delivery efficacy of NPs tends to be heterogeneous in clinical research. Surprisingly, a traditional cancer treatment, radiotherapy (radiation), has been observed with the potential to improve the delivery of NPs by influencing the features of the tumor microenvironment, which provides new perspectives to overcome the barriers in the NPs delivery. Since the effect of radiation can also be enhanced by versatile NPs, these findings of radiation-assisted NPs delivery suggest innovative strategies combining radiotherapy with nanotherapeutics. This review summarizes the research on the delivery and therapeutic efficacy of NPs that are improved by radiation, focusing on relative mechanisms and existing challenges and opportunities.

Keywords: Cancer therapy; Drug delivery; Nanoparticle; Radiotherapy pretreatment; Tumor distribution.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / therapeutic use
Drug Delivery Systems
Humans
Nanoparticles* / therapeutic use
Neoplasms* / drug therapy
Tumor Microenvironment

Substances

Antineoplastic Agents