Perfluoroalkyl and polyfluoroalkyl substances in cord serum of newborns and their potential factors

Jingwen Jia; Lihong Duan; Bingqi Dong; Qiuying Dong; Yinping Liu; Wanqin Yu; Lixin Yang; Hongmei Shi

doi:10.1016/j.chemosphere.2022.137525

Perfluoroalkyl and polyfluoroalkyl substances in cord serum of newborns and their potential factors

Chemosphere. 2023 Feb:313:137525. doi: 10.1016/j.chemosphere.2022.137525. Epub 2022 Dec 12.

Authors

Jingwen Jia¹, Lihong Duan², Bingqi Dong³, Qiuying Dong⁴, Yinping Liu⁴, Wanqin Yu¹, Lixin Yang⁵, Hongmei Shi⁶

Affiliations

¹ Hebei Center for Disease Control and Prevention, Shijiazhuang, 050021, China; Key Laboratory of Environment and Human Health of Hebei Province; School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.
² The Fourth Hospital of Shijiazhuang, Shijiazhuang, 050011, China.
³ The MOE Key Laboratory of Resource and Environmental System Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China.
⁴ Hebei Center for Disease Control and Prevention, Shijiazhuang, 050021, China.
⁵ Hebei Center for Disease Control and Prevention, Shijiazhuang, 050021, China. Electronic address: yanglixin241@163.com.
⁶ Key Laboratory of Environment and Human Health of Hebei Province; School of Public Health, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address: hongmshi@163.com.

PMID: 36521747
DOI: 10.1016/j.chemosphere.2022.137525

Abstract

The demonstrated developmental and reproductive toxicity of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), coupled with the increasing production and use of emerging per- and polyfluoroalkyl substances (PFASs) has resulted in progressively higher human exposure levels. This has raised concerns about PFAS exposure levels in the fetus, which is highly susceptible to the potential effects of hazardous environmental chemicals. However, in utero exposure to PFASs and health implications have not been fully characterized in China. To fill this gap, we analyzed 19 PFASs in umbilical cord serum samples (n = 66). Information about the mothers and newborns was obtained through questionnaires. Associations between maternal characteristics and neonatal birth weight and PFAS concentrations were analyzed using nonparametric tests. As results, PFOA was detected in all serum samples. The highest median concentration of PFOS in umbilical serum was 1.092 ng·mL^-1, followed by perfluoropentanoic acid (median: 0.633 ng·mL^-1). Trifluroacetic acid and perfluoropropanoic acid were detected in cord serum for the first time, and their median concentrations were 0.229 and 0.266 ng·mL^-1, respectively. Neonatal birth weight was negatively correlated with long-chain PFOS (r = -0.319, P < 0.05), and the concentrations of perfluoroundecanoic acid and perfluorododecanoic acid were significantly different between the birth weight groups. Maternal age, maternal education, diet, and nutritional supplementation during pregnancy can all affect umbilical serum exposure to PFASs. These results demonstrate that legacy PFASs remain major contributors to the composition of human PFASs, while the concentration levels of emerging short-chain alternatives have increased significantly. Modifying the mother's diet may reduce the risk of intrauterine PFAS exposure. Special attention to exposure to highly novel PFASs and confirmation of potential determinants should be taken as a priority in the plan for risk management and actions in this area.

Keywords: Cord serum; Influencing factors; Perfluoroalkyl substances.

MeSH terms

Alkanesulfonic Acids*
Birth Weight
China
Environmental Pollutants*
Female
Fluorocarbons*
Humans
Infant, Newborn
Pregnancy

Substances

Environmental Pollutants
Fluorocarbons
perfluorooctanoic acid
perfluorooctane sulfonic acid
Alkanesulfonic Acids