Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19

Matthias H Busch; Sjoerd A M E G Timmermans; Sander M J Van Kuijk; Joop P Aendekerk; Renée Ysermans; Daan P C Van Doorn; Judith Potjewijd; Marcel C G Van de Poll; Iwan C C Van der Horst; Jan G M C Damoiseaux; Henri M H Spronk; Hugo Ten Cate; Chris P Reutelingsperger; Magdolna Nagy; Pieter Van Paassen

doi:10.3324/haematol.2022.281693

Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19

Haematologica. 2023 May 1;108(5):1417-1422. doi: 10.3324/haematol.2022.281693.

Authors

Matthias H Busch¹, Sjoerd A M E G Timmermans¹, Sander M J Van Kuijk², Joop P Aendekerk³, Renée Ysermans³, Daan P C Van Doorn³, Judith Potjewijd¹, Marcel C G Van de Poll⁴, Iwan C C Van der Horst⁴, Jan G M C Damoiseaux⁵, Henri M H Spronk⁶, Hugo Ten Cate⁶, Chris P Reutelingsperger³, Magdolna Nagy³, Pieter Van Paassen⁷

Affiliations

¹ Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht.
² Dept. of Clinical Epidemiology and Medical Technology Assessment.
³ Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht.
⁴ Dept. Intensive Care Medicine.
⁵ Central Diagnostic Laboratory.
⁶ Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht.
⁷ Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht. p.vanpaassen@maastrichtuniversity.nl.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Blood Coagulation
COVID-19*
Factor VIII / metabolism
Humans
Patient Acuity
Thrombin / metabolism
von Willebrand Diseases*
von Willebrand Factor / metabolism

Substances

von Willebrand Factor
Thrombin
Factor VIII

Grants and funding

Funding: HC and HMHS receive grant support from the Netherlands Heart Foundation (CVON2014-09, Reappraisal of Atrial Fibrillation: Interaction between HyperCoagulability, Electrical Remodeling, and Vascular Destabilization in the Progression of Atrial Fibrillation (RACE V), and from REG-MED XB: Cardiovascular Moonshot. HC was supported by a fellowship of the Gutenberg University Mainz. MV is supported in part by funding from a Health-Holland project/partnership grant (LSHM 9111).