Hemosiderin Detection inside the Mammillary Bodies Using Quantitative Susceptibility Mapping on Patients with Wernicke-Korsakoff Syndrome

Magn Reson Med Sci. 2024 Jan 1;23(1):14-17. doi: 10.2463/mrms.ici.2022-0109. Epub 2022 Dec 13.

Abstract

Hemorrhage inside the mammillary bodies (MMBs) is known to be one of the findings of Wernicke encephalopathy. Brain MRI of two patients with Wernicke-Korsakoff syndrome (WKS) demonstrated high susceptibility values representing hemosiderin deposition in MMBs by using quantitative susceptibility mapping (QSM). QSM provided additional information of susceptibility values to susceptibility-weighted imaging in diagnosis of WKS.

Keywords: Wernicke-Korsakoff syndrome; mammillary body; quantitative susceptibility mapping.

MeSH terms

  • Hemosiderin
  • Humans
  • Korsakoff Syndrome* / diagnosis
  • Korsakoff Syndrome* / pathology
  • Magnetic Resonance Imaging
  • Mammillary Bodies / diagnostic imaging
  • Mammillary Bodies / pathology
  • Wernicke Encephalopathy* / diagnostic imaging
  • Wernicke Encephalopathy* / pathology

Substances

  • Hemosiderin

Grants and funding

This work was supported by JSPS KAKENHI Grant Numbers 21K20834, 21K15623, 21K15826, and 22K07746.