Tipping the balance: New insights into stromal regulation of cancer

Joana Leitão Castro; Janine Terra Erler

doi:10.1016/j.ccell.2022.11.011

Tipping the balance: New insights into stromal regulation of cancer

Cancer Cell. 2022 Dec 12;40(12):1467-1469. doi: 10.1016/j.ccell.2022.11.011.

Authors

Joana Leitão Castro¹, Janine Terra Erler²

Affiliations

¹ Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
² Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, 2200 Copenhagen, Denmark. Electronic address: janine.erler@bric.ku.dk.

PMID: 36513048
DOI: 10.1016/j.ccell.2022.11.011

Abstract

Desmoplastic extracellular matrix (ECM) exerts a seemingly paradoxical role in cancer, restricting or promoting progression. Two recent back-to-back Nature reports shed light on this conundrum, revealing the role of different hepatic stellate cell (HSC) populations and different collagen I cleavage states in directing the progression of cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Collagen Type I
Extracellular Matrix
Hepatic Stellate Cells*
Humans
Kupffer Cells
Liver Cirrhosis
Neoplasms* / genetics

Substances

Collagen Type I