Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location

Terri Shih; Susy Yusung; Rivkah Gonsky; Rhiannon Dutra-Clarke; David Ziring; Shervin Rabizadeh; Subra Kugathasan; Lee A Denson; Dalin Li; Jonathan Braun

doi:10.1093/ibd/izac251

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location

Inflamm Bowel Dis. 2023 Feb 1;29(2):328-331. doi: 10.1093/ibd/izac251.

Authors

Affiliations

¹ David Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA.
² Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
³ Emory University School of Medicine, Atlanta, GA, 30322, USA.
⁴ Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.

No abstract available

Keywords: HLA; KIR; cytomegalovirus; inflammatory bowel disease.

Plain language summary

Active cytomegalovirus (CMV) infection complicates management of inflammatory bowel disease, but the relationship of resolved CMV infection to Crohn’s disease (CD) behavior or localization is unknown. This article reports a striking risk (9-fold) of Crohn’s disease localization to the colon with prior CMV infection. It also reports imputed mucosal cellular composition, HLA class 1, and KIR gene variants that delimit prior observations regarding HLA and KIR associations with Crohn’s disease risk and behavior.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Crohn Disease* / complications
Cytomegalovirus Infections* / complications
Herpesviridae Infections*
Humans
Inflammatory Bowel Diseases*

Plain language summary

Publication types

MeSH terms

Grants and funding