Application of Mn x Fe1- x Fe2O4 (x = 0-1) Nanoparticles in Magnetic Fluid Hyperthermia: Correlation with Cation Distribution and Magnetostructural Properties

Satish S Phalake; Manohar S Lad; Ketaki V Kadam; Syed A M Tofail; Nanasaheb D Thorat; Vishwajeet M Khot

doi:10.1021/acsomega.2c05651

Application of Mn _x Fe_{1- x} Fe₂O₄ (x = 0-1) Nanoparticles in Magnetic Fluid Hyperthermia: Correlation with Cation Distribution and Magnetostructural Properties

ACS Omega. 2022 Nov 22;7(48):44187-44198. doi: 10.1021/acsomega.2c05651. eCollection 2022 Dec 6.

Authors

Satish S Phalake¹, Manohar S Lad¹, Ketaki V Kadam¹, Syed A M Tofail², Nanasaheb D Thorat^{2

3}, Vishwajeet M Khot¹

Affiliations

¹ Department of Medical Physics, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Institution Deemed to Be University), Kolhapur416 006, Maharashtra, India.
² Department of Physics and Bernal Institute, University of Limerick, Castletroy, Co. Limerick, LimerickV94T9PX, Ireland.
³ Nuffield Department of Women's and Reproductive Health, John Radcliffe Hospital, Medical Sciences Division, University of Oxford, OxfordOX3 9DU, U.K.

Abstract

Optimization of manganese-substituted iron oxide nanoferrites having the composition Mn _x Fe_1-x Fe₂O₄ (x = 0-1) has been achieved by the chemical co-precipitation method. The crystallite size and phase purity were analyzed from X-ray diffraction. With increases in Mn²⁺ concentration, the crystallite size varies from 5.78 to 9.94 nm. Transmission electron microscopy (TEM) analysis depicted particle sizes ranging from 10 ± 0.2 to 13 ± 0.2 nm with increasing Mn²⁺ substitution. The magnetization (M _s) value varies significantly with increasing Mn²⁺ substitution. The variation in the magnetic properties may be attributed to the substitution of Fe²⁺ ions by Mn²⁺ ions inducing a change in the superexchange interaction between the A and B sublattices. The self-heating characteristics of Mn _x Fe_1-x Fe₂O₄ (x = 0-1) nanoparticles (NPs) in an AC magnetic field are evaluated by specific absorption rate (SAR) and intrinsic loss power, both of which are presented with varying NP composition, NP concentration, and field amplitudes. Mn_0.75Fe_0.25Fe₂O₄ exhibited superior induction heating properties in terms of a SAR of 153.76 W/g. This superior value of SAR with an optimized Mn²⁺ content is presented in correlation with the cation distribution of Mn²⁺ in the A or B position in the Fe₃O₄ structure and enhancement in magnetic saturation. These optimized Mn_0.75Fe_0.25Fe₂O₄ NPs can be used as a promising candidate for hyperthermia applications.