Roles and mechanisms of CircRNAs in ovarian cancer

Min Liu; Siyu Cao; Ziyi Guo; Zong Wu; Jiao Meng; Yong Wu; Yang Shao; Yanli Li

doi:10.3389/fcell.2022.1044897

Roles and mechanisms of CircRNAs in ovarian cancer

Front Cell Dev Biol. 2022 Nov 23:10:1044897. doi: 10.3389/fcell.2022.1044897. eCollection 2022.

Authors

Min Liu¹, Siyu Cao², Ziyi Guo¹, Zong Wu³, Jiao Meng^{4

5}, Yong Wu^{5

2}, Yang Shao^{4

5}, Yanli Li¹

Affiliations

¹ Lab for Noncoding RNA and Cancer, School of Life Sciences, Shanghai University, Shanghai, China.
² Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
³ Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁴ Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
⁵ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Abstract

Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that circRNAs have different biological function, including sponging miRNAs, encoding micropeptides, regulating stability of cytoplasmic mRNAs, affecting transcription and splicing, via interacting with DNA, RNA and proteins. Due to their stability, circRNAs have the potential of acting as biomarkers and treatment targets. In this review, we briefly illustrate the biogenesis mechanism and biological function of circRNAs in OC, and make a perspective of circRNAs drug targeting immune responses and signaling pathways in OC. This article can provide a systematic view into the current situation and future of circRNAs in OC.

Keywords: CircRNAs; biosynthesis; drug; function; ovarian cancer.

Publication types

Review