The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Front Endocrinol (Lausanne). 2022 Nov 24:13:1069057. doi: 10.3389/fendo.2022.1069057. eCollection 2022.

Abstract

Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered biomechanics. Inflammation and immunity play an important role in the pathogenesis of OA. JAK/STAT pathway is one of the most prominent intracellular signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Inflammatory factors can act as the initiators of JAK/STAT pathway, which is implicated in the pathophysiological activity of chondrocyte. In this article, we provide a review on the importance of JAK/STAT pathway in the pathological development of OA. Potentially, JAK/STAT pathway becomes a therapeutic target for managing OA.

Keywords: JAK/STAT pathway; SOCS; cartilage remodeling; inflammation; osteoarthritis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chondrocytes / metabolism
  • Humans
  • Janus Kinases / metabolism
  • Janus Kinases / therapeutic use
  • Osteoarthritis* / etiology
  • Osteoarthritis* / metabolism
  • STAT Transcription Factors* / metabolism
  • STAT Transcription Factors* / therapeutic use
  • Signal Transduction / physiology

Substances

  • STAT Transcription Factors
  • Janus Kinases