Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [ Glycine max (L.) Merr.]

Ayyagari Ramlal; Aparna Nautiyal; Pooja Baweja; Vikash Kumar; Sahil Mehta; Rohit Kumar Mahto; Shikha Tripathi; Aravindam Shanmugam; Bingi Pujari Mallikarjuna; Pushpa Raman; S K Lal; Dhandapani Raju; Ambika Rajendran

doi:10.3389/fnut.2022.1068388

Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [ Glycine max (L.) Merr.]

Front Nutr. 2022 Nov 24:9:1068388. doi: 10.3389/fnut.2022.1068388. eCollection 2022.

Authors

Affiliations

¹ Division of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), New Delhi, India.
² Department of Botany, Deshbandhu College, University of Delhi, New Delhi, India.
³ Department of Botany, Maitreyi College, University of Delhi, New Delhi, India.
⁴ Faculty of Agricultural Sciences, Institute of Applied Sciences and Humanities, GLA University, Mathura, Uttar Pradesh, India.
⁵ Department of Botany, Hansraj College, University of Delhi, New Delhi, India.
⁶ School of Biotechnology, Institute of Science, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India.
⁷ Indian Council of Agricultural Research (ICAR)-National Institute for Plant Biotechnology (NIPB), New Delhi, India.
⁸ Department of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India.
⁹ Centre for Plant Breeding and Genetics, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India.
¹⁰ Division of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), Regional Research Centre, Dharwad, Karnataka, India.
¹¹ Department of Plant Breeding and Genetics, Tamil Nadu Rice Research Institute, Tamil Nadu Agricultural University, Aduthurai, Tamil Nadu, India.
¹² Division of Plant Physiology, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute, New Delhi, India.

Abstract

Angiotensin-converting enzyme I (ACE I) is a zinc-containing metallopeptidase involved in the renin-angiotensin system (RAAS) that helps in the regulation of hypertension and maintains fluid balance otherwise, which results in cardiovascular diseases (CVDs). One of the leading reasons of global deaths is due to CVDs. RAAS also plays a central role in maintaining homeostasis of the CV system. The commercial drugs available to treat CVDs possess several fatal side effects. Hence, phytochemicals like peptides having plant-based origin should be explored and utilized as alternative therapies. Soybean is an important leguminous crop that simultaneously possesses medicinal properties. Soybean extracts are used in many drug formulations for treating diabetes and other disorders and ailments. Soy proteins and its edible products such as tofu have shown potential inhibitory activity against ACE. Thus, this review briefly describes various soy proteins and products that can be used to inhibit ACE thereby providing new scope for the identification of potential candidates that can help in the design of safer and natural treatments for CVDs.

Keywords: angiotensin-converting enzyme I (ACE I); cardiovascular diseases (CVDs); natural drugs; renin-angiotensin-aldosterone system (RAAS); soy products.