Hyperfunctioning parathyroid gland and skeletal involvement on [18F]fluorocholine PET/CT: one look with two views

Carmela Nappi; Leandra Piscopo; Michele Klain; Ciro Gabriele Mainolfi; Emilia Vergara; Daniela Adamo; Michele Davide Mignogna; Alberto Cuocolo

doi:10.1186/s41824-022-00149-y

Hyperfunctioning parathyroid gland and skeletal involvement on [¹⁸F]fluorocholine PET/CT: one look with two views

Eur J Hybrid Imaging. 2022 Dec 12;6(1):28. doi: 10.1186/s41824-022-00149-y.

Authors

Carmela Nappi¹, Leandra Piscopo¹, Michele Klain¹, Ciro Gabriele Mainolfi¹, Emilia Vergara¹, Daniela Adamo², Michele Davide Mignogna², Alberto Cuocolo³

Affiliations

¹ Department of Advanced Biomedical Sciences, University of Naples Federico II, Napoli, Italy.
² Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Napoli, Italy.
³ Department of Advanced Biomedical Sciences, University of Naples Federico II, Napoli, Italy. cuocolo@unina.it.

Abstract

Hyperparathyroidism is an endocrine disorder that may be associated with other metabolic diseases. Non-invasive imaging techniques including [^99mTc]Tc-sestamibi single-photon emission computed tomography (SPECT) and [¹⁸F]fluorocholine positron emission tomography (PET)/computed tomography (CT) play a key role on management of patients with hyperparathyroidism. We report for the first time a case of a patient with evidence of both hyperfunctioning parathyroid tissue and multiple lytic bone lesions on [¹⁸F]fluorocholine PET/CT imaging. The present case report highlights the potential role of whole-body [¹⁸F]fluorocholine PET/CT for the identification of both parathyroid adenoma and multiple bone lesions in a single diagnostic setting.