Phantom-based evaluation of yttrium-90 datasets using biograph vision quadra

Konstantinos G Zeimpekis; Lorenzo Mercolli; Maurizio Conti; Hasan Sari; George Prenosil; Kuangyu Shi; Axel Rominger

doi:10.1007/s00259-022-06074-3

Phantom-based evaluation of yttrium-90 datasets using biograph vision quadra

Eur J Nucl Med Mol Imaging. 2023 Mar;50(4):1168-1182. doi: 10.1007/s00259-022-06074-3. Epub 2022 Dec 12.

Authors

Konstantinos G Zeimpekis¹, Lorenzo Mercolli², Maurizio Conti³, Hasan Sari⁴, George Prenosil², Kuangyu Shi², Axel Rominger²

Affiliations

¹ Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. konstantinos.zeimpekis@insel.ch.
² Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
³ Molecular Imaging, Siemens Healthineers, Knoxville, TN, USA.
⁴ Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.

Abstract

Purpose: The image quality characteristics of two NEMA phantoms with yttrium-90 (⁹⁰Y) were evaluated on a long axial field-of-view (AFOV) PET/CT. The purpose was to identify the optimized reconstruction setup for the imaging of patients with hepatocellular carcinoma after ⁹⁰Y radioembolization.

Methods: Two NEMA phantoms were used, where one had a 1:10 sphere to background activity concentration ratio and the second had cold background. Reconstruction parameters used are as follows: iterations 2 to 8, Gaussian filter 2- to 6-mm full-width-at-half-maximum, reconstruction matrices 440 × 440 and 220 × 220, high sensitivity (HS), and ultra-high sensitivity (UHS) modes. 50-, 40-, 30-, 20-, 10-, and 5-min acquisitions were reconstructed. The measurements included recovery coefficients (RC), signal-to-noise ratio (SNR), background variability, and lung error which measures the residual error in the corrections. Patient data were reconstructed with 20-, 10-, 5-, and 1-min time frames and evaluated in terms of SNR.

Results: The RC for the hot phantom was 0.36, 0.45, 0.53, 0.63, 0.68, and 0.84 for the spheres with diameters of 10, 13, 17, 22, 28, and 37 mm, respectively, for UHS 2 iterations, a 220 × 220 matrix, and 50-min acquisition. The RC values did not differ with acquisition times down to 20 min. The SNR was the highest for 2 iterations, measured 11.7, 16.6, 17.6, 19.4, 21.9, and 27.7 while the background variability was the lowest (27.59, 27.08, 27.36, 26.44, 30.11, and 33.51%). The lung error was 18%. For the patient dataset, the SNR was 19%, 20%, 24%, and 31% higher for 2 iterations compared to 4 iterations for 20-, 10-, 5-, and 1-min time frames, respectively.

Conclusions: This study evaluates the NEMA image quality of a long AFOV PET/CT scanner with ⁹⁰Y. It provides high RC for the smallest sphere compared to other standard AFOV scanners at shorter scan times. The maximum patient SNR was for 2 iterations, 20 min, while 5 min delivers images with acceptable SNR.

Keywords: Image quality; NEMA; Quadra; Whole-body PET/CT; Yttrium-90.

MeSH terms

Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / radiotherapy
Phantoms, Imaging
Positron Emission Tomography Computed Tomography*
Positron-Emission Tomography / methods
Yttrium Radioisotopes / therapeutic use

Substances

Yttrium-90
Yttrium Radioisotopes