Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release

Rostyslav Horbay; Ali Hamraghani; Leonardo Ermini; Sophie Holcik; Shawn T Beug; Behzad Yeganeh

doi:10.3390/ijms232315317

Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release

Int J Mol Sci. 2022 Dec 5;23(23):15317. doi: 10.3390/ijms232315317.

Authors

Rostyslav Horbay^{1

2}, Ali Hamraghani^{1

3}, Leonardo Ermini⁴, Sophie Holcik¹, Shawn T Beug^{1

2

5}, Behzad Yeganeh^{1

3}

Affiliations

¹ Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada.
² Centre for Infection, Immunity and Inflammation (CI3), University of Ottawa, Ottawa, ON K1H 8L1, Canada.
³ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
⁴ Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
⁵ Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8L1, Canada.

Abstract

Cells have the ability to communicate with their immediate and distant neighbors through the release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the packaging of specific cargo in all type of cells, and perturbations of EV biogenesis, sorting, release and uptake is the basis of a number of disorders. In this review, we summarize recent advances of the complex roles of the sphingolipid ceramide and lysosomes in the journey of EV biogenesis to uptake.

Keywords: ESCRT-dependent pathway; ESCRT-independent pathway; exosome; intraluminal vesicles; mitochondria-derived vesicle; multivesicular body.

Publication types

Review

MeSH terms

Biological Transport
Ceramides* / metabolism
Extracellular Vesicles* / metabolism
Lysosomes
Protein Transport

Substances

Ceramides

Grants and funding

This research was funded by Cancer Research Society [935202, S.T.B.] and Canadian Institutes of Heath Research [426713, S.T.B.].