Neuropharmacological effect of risperidone: From chemistry to medicine

Asif Ahmad Bhat; Gaurav Gupta; Obaid Afzal; Imran Kazmi; Fahad A Al-Abbasi; Abdulmalik Saleh Alfawaz Altamimi; Waleed Hassan Almalki; Sami I Alzarea; Sachin Kumar Singh; Kamal Dua

doi:10.1016/j.cbi.2022.110296

Neuropharmacological effect of risperidone: From chemistry to medicine

Chem Biol Interact. 2023 Jan 5:369:110296. doi: 10.1016/j.cbi.2022.110296. Epub 2022 Dec 7.

Authors

Affiliations

¹ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India.
² School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India. Electronic address: gauravpharma25@gmail.com.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia.
⁴ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁵ Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁶ Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
⁷ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia.
⁸ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia.

PMID: 36496108
DOI: 10.1016/j.cbi.2022.110296

Abstract

As the second-oldest atypical antipsychotic, risperidone has a long history of off-label usage for treating behavioural and psychological signs and symptoms of dementia (BPSD), such as agitation, aggressiveness, and psychosis. Risperidone has been shown in several trials to have a statistically significant benefit when used in a therapeutic context. Several lines of evidence suggest a possible role of risperidone via the antagonistic effect of Dopamine D2 and 5HT-receptor in different neurological diseases like cognitive dysfunction of schizophrenia, neuroinflammation, Huntington's disease, and sleep cycle management. Therefore, the pharmacological interactions of risperidone in all these diseases were investigated. Some reports on the use of risperidone in the treatment of dopaminergic psychosis have been slightly conflicting. However, more research is needed to evaluate the role of risperidone in the treatment of these neurological diseases.

Keywords: Dopaminergic psychosis; Neuroinflammation; Neurological diseases; Neuropharmacological treatment; Risperidone.

Publication types

Review

MeSH terms

Antipsychotic Agents* / pharmacology
Antipsychotic Agents* / therapeutic use
Humans
Huntington Disease* / drug therapy
Psychotic Disorders* / drug therapy
Risperidone / pharmacology
Risperidone / therapeutic use
Schizophrenia*

Substances

Risperidone
Antipsychotic Agents