The therapeutic benefits of phenolic compounds found in plants are well known. The purpose of this study was to determine the phenolic content of ten plant species used as ethnoveterinary treatments in Namibia's Omusati and Kunene regions. The plants of concern were Aloe esculenta, Fockea angustifolia, Boscia albitrunca, Combretum imberbe, Acacia nilotica, Colophospermum mopane, Acacia erioloba, Ziziphus mucronata, Ximenia americana, and Salvadora persica. An LC-MS approach was used to identify the compounds. To analyse high-resolution UPLC-UV/MS, a Waters Acquity ultra-performance liquid chromatograph (UPLC) with a photodiode array detector was connected to a Waters Synapt G2 quadrupole time-of-flight mass spectrometer (MS). The current study identified a total of 29 phenolic compounds. Flavonoids (epicatechin, (-)-Epigallocatechin, and rutin,) were the most abundant, followed by 2R, 3S-Piscidic acid. Methylisocitric acid was found in all species investigated, with the highest quantities in A. esculenta and X. americana leaf extracts. There were differences in composition and quantity of phenolic compounds in aerial and ground sections between species. The overall findings of the present study would act as a standard for subsequent investigations into the pharmacological potentials of plants species utilized as ethnoveterinary remedies. Priority should be given to isolating, purifying, and defining the active compounds responsible for these plants' activity.
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