Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors

Wenjing Sun; Chengchao Chu; Shi Li; Xiaoqian Ma; Peifei Liu; Shileng Chen; Hongmin Chen

doi:10.1016/j.addr.2022.114643

Nanosensitizer-mediated unique dynamic therapy tactics for effective inhibition of deep tumors

Adv Drug Deliv Rev. 2023 Jan:192:114643. doi: 10.1016/j.addr.2022.114643. Epub 2022 Dec 6.

Authors

Wenjing Sun¹, Chengchao Chu², Shi Li³, Xiaoqian Ma³, Peifei Liu³, Shileng Chen³, Hongmin Chen⁴

Affiliations

¹ ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
² Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Engineering Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen 361102, China.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
⁴ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. Electronic address: hchen@xmu.edu.cn.

PMID: 36493905
DOI: 10.1016/j.addr.2022.114643

Abstract

X-ray and ultrasound waves are widely employed for diagnostic and therapeutic purposes in clinic. Recently, they have been demonstrated to be ideal excitation sources that activate sensitizers for the dynamic therapy of deep-seated tumors due to their excellent tissue penetration. Here, we focused on the recent progress in five years in the unique dynamic therapy strategies for the effective inhibition of deep tumors that activated by X-ray and ultrasound waves. The concepts, mechanisms, and typical nanosensitizers used as energy transducers are described as well as their applications in oncology. The future developments and potential challenges are also discussed. These unique therapeutic methods are expected to be developed as depth-independent, minimally invasive, and multifunctional strategies for the clinic treatment of various deep malignancies.

Keywords: Cancer theranostics; Deep tumors; Nanosensitizers; Sonodynamic therapy; X-ray induced photodynamic therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Neoplasms* / pathology
Photochemotherapy* / methods
X-Rays