Immune cell interactions in tuberculosis

JoAnne L Flynn; John Chan

doi:10.1016/j.cell.2022.10.025

Immune cell interactions in tuberculosis

Cell. 2022 Dec 8;185(25):4682-4702. doi: 10.1016/j.cell.2022.10.025.

Authors

JoAnne L Flynn¹, John Chan²

Affiliations

¹ Department of Microbiology and Molecular Genetics and the Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: joanne@pitt.edu.
² Department of Medicine, Center for Emerging Pathogens, Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address: jc2864@njms.rutgers.edu.

PMID: 36493751
DOI: 10.1016/j.cell.2022.10.025

Abstract

Despite having been identified as the organism that causes tuberculosis in 1882, Mycobacterium tuberculosis has managed to still evade our understanding of the protective immune response against it, defying the development of an effective vaccine. Technology and novel experimental models have revealed much new knowledge, particularly with respect to the heterogeneity of the bacillus and the host response. This review focuses on certain immunological elements that have recently yielded exciting data and highlights the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.

Publication types

Review

MeSH terms

Cell Communication
Humans
Mycobacterium tuberculosis*
Tuberculosis* / immunology

Grants and funding

R01 AI139297/AI/NIAID NIH HHS/United States