Social and communication skills play an important role in the relationship between healthcare professionals and their patients. In this field, it is plausible that clinical empathy and loneliness play an important role of influence. However, the knowledge about this roll is still scarce. The main purpose of this review was to collect findings reported on this matter in students and healthcare professionals. The review included: articles published in English or Spanish during the last fifty years that were indexed in MedLine or SCOPUS, with students or health professionals as participants, and where empathy and loneliness had been used as main measures. Eleven articles, published between 1986 and 2020, that met the abovementioned criteria were included in the analysis. From them, eight corresponded to observational studies and three to interventional studies. Eight studies included students and the other three included healthcare professionals in their study samples. A negative correlation between empathy and loneliness was found in four studies. Furthermore, loneliness in the family environment was described as a negative predictor of empathy towards patients. Training programs in empathic skills and group accompaniment proved not only effective in the improvement of empathy in students, but also in the reduction of loneliness. These findings confirm a close relationship between clinical empathy and loneliness. They also show that the improvement in empathic skills not only has a positive effect on the professional ethical behavior towards patients, but it also helps improving the professional's well-being by reducing loneliness.