Circulation of a single hepatitis A virus genotype IIIA with two distinct clusters in different states of India

Indian J Med Microbiol. 2023 May-Jun:43:96-100. doi: 10.1016/j.ijmmb.2022.11.003. Epub 2022 Dec 5.

Abstract

With the changing hepatitis A epidemiology in India, focal viral outbreaks are being reported from different parts of the country. This study presents Hepatitis A Virus (HAV) strain characterization (period 2009-2020) from 18 states of India. For that, blood and stool samples (n ​= ​280) were screened for HAV RNA and sequences for 5'non-coding and VP3 regions were generated from positive samples (n ​= ​68). Presence of a single IIIA genotype in all samples indicated IIIA being the only HAV genotype currently circulating in India. Interestingly, it was evident that these strains form two distinct groups suggesting independent evolution of these two clusters.

Keywords: Circulating genotypes; Hepatitis A; India.

MeSH terms

  • Feces / chemistry
  • Feces / virology
  • Genotype
  • Hepatitis A Virus, Human* / classification
  • Hepatitis A Virus, Human* / genetics
  • Hepatitis A Virus, Human* / isolation & purification
  • Hepatitis A* / blood
  • Hepatitis A* / epidemiology
  • Hepatitis A* / virology
  • Humans
  • India / epidemiology
  • Phylogeny
  • RNA, Viral / analysis

Substances

  • RNA, Viral