Identification of two novel HLA-DQB103:01:01 intronic variants: HLA-DQB103:01:01:47 and -DQB1*03:01:01:48

HLA. 2023 May;101(5):562-564. doi: 10.1111/tan.14935. Epub 2022 Dec 27.

Authors

Francisco Javier Gil Etayo^{1

2}, Jairo Eduardo Niño Ramírez^{1

2

3}, Ariadna Vicente Parra¹, Ramón García Sanz^{1

2

3

4

5}, Amalia Tejeda Velarde^{1

2}

Affiliations

¹ Laboratorio de HLA-Biología Molecular, Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain.
² Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
³ Universidad de Salamanca (USAL), Salamanca, Spain.
⁴ Centro de Investigación del Cáncer (CIC), Salamanca, Spain.
⁵ Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.

PMID: 36480174
DOI: 10.1111/tan.14935

Abstract

Two different single nucleotide substitutions in intron 1 give rise to the alleles HLA-DQB1*03:01:01:47 and DQB1*03:01:01:48.

Keywords: HLA-DQB1*03:01:01:47; HLA-DQB1*03:01:01:48; HLA typing; new allele; next-generation sequencing.

© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH terms

Alleles*
HLA-DQ beta-Chains / genetics
Humans
Introns
Mutation

Substances

HLA-DQB1 antigen
HLA-DQ beta-Chains