Role of Nanozymes in Oral Cancer the Road Ahead

Dominic Augustine; S V Sowmya; Neethi Gujjar; C Pushpalatha; Vanishri C Haragannavar

doi:10.1007/s11244-022-01729-9

Role of Nanozymes in Oral Cancer the Road Ahead

Top Catal. 2022;65(19-20):1973-1983. doi: 10.1007/s11244-022-01729-9. Epub 2022 Nov 23.

Authors

Dominic Augustine¹, S V Sowmya¹, Neethi Gujjar¹, C Pushpalatha², Vanishri C Haragannavar¹

Affiliations

¹ Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, Karnataka 560054 India.
² Department of Pedodontics & Preventive Dentistry, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, Karnataka 560054 India.

Abstract

Oral cancer is a result of diverse interactions in the tumor microenvironment (TME), genetic alterations along with associated risk factors such as lifestyle and microbial infections. Various modalities are employed in the diagnosis and therapeutics of oral cancer. Nanozymes which are artificial enzymes have a great potential in the diagnostic and therapeutic approach of tumors. They have enormous advantages compared to natural enzymes and possess inherent biological and physical properties. A web-based search was performed via the Google scholar, PubMed database, Web of Science with keywords nanozymes, nanoparticles in cancer and oral cancer. The other keywords used were diagnosis, therapy, TME, microbiome, molecular alterations, biosensor, targeted therapy, imaging and tissue regeneration. Original research studies, reviews, case reports published from 2012 to 2022 were included to appraise different subsections. An absolute lack of literature on nanozymes was observed in oral cancer. The present review is the first attempt to describe the role and application of nanozymes in oral cancer by correlating its outcome in tumor biology and biomedical research. Rapid development of nanotechnology has created a paradigm shift in cancer diagnosis and therapeutics. Nanozymes with novel designs can be anticipated in the future in oral cancer management.

Supplementary information: The online version contains supplementary material available at 10.1007/s11244-022-01729-9.

Keywords: Biosensing; Cancerimaging; Genetics; Microbiome; Nanoparticles; Nanozymes; Oral cancer; Regeneration; Tumor microenvironment.

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