Acquired Hemophilia in an Elderly Patient with Non-Small Cell Lung Cancer: a Case Report

Antonio Dulcetti; C Bruscia; D M Malena; R Benvenuto; A Martocchia; A Sentimetale; L Tafaro; Massimiliano Rocchietti March; P Martelletti

doi:10.1007/s42399-022-01330-x

Acquired Hemophilia in an Elderly Patient with Non-Small Cell Lung Cancer: a Case Report

SN Compr Clin Med. 2023;5(1):7. doi: 10.1007/s42399-022-01330-x. Epub 2022 Nov 23.

Authors

Antonio Dulcetti¹, C Bruscia¹, D M Malena¹, R Benvenuto¹, A Martocchia¹, A Sentimetale¹, L Tafaro¹, Massimiliano Rocchietti March¹, P Martelletti¹

Affiliation

¹ UOC Medicina d'Urgenza, Azienda Ospedaliera-Universitaria Sant'Andrea, Università Degli Studi Di Roma La Sapienza, Via di Grottarossa, 1035, Rome, 00189 Italy.

Abstract

Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies against coagulation factor VIII and characterized by spontaneous hemorrhage in patients with no previous family or personal history of bleeding. We report here a case of AHA that occurred in the Department of Medicina D'Urgenza in Sant'Andrea Hospital in a patient with previous diagnosis of NSLC. The aim of this article is to allow a more comprehensive knowledge of AHA that both for the rarity and the poor literature is underdiagnosed; for all these reasons, it is important that different specialists, like emergency specialists, experts in internal medicine, hematologists, and oncologists, acquire a more complete knowledge of the clinical and laboratory features of this disease, allowing an early diagnosis crucial for the evolution of the coagulopathy.

Keywords: Acquired hemophilia A; Bleeding; Case report; Paraneoplastic; Recombinant activated factor VII.

Publication types

Case Reports