ResNet-32 and FastAI for diagnoses of ductal carcinoma from 2D tissue slides

Sci Rep. 2022 Dec 2;12(1):20804. doi: 10.1038/s41598-022-25089-2.

Abstract

Carcinoma is a primary source of morbidity in women globally, with metastatic disease accounting for most deaths. Its early discovery and diagnosis may significantly increase the odds of survival. Breast cancer imaging is critical for early identification, clinical staging, management choices, and treatment planning. In the current study, the FastAI technology is used with the ResNet-32 model to precisely identify ductal carcinoma. ResNet-32 is having few layers comparted to majority of its counterparts with almost identical performance. FastAI offers a rapid approximation toward the outcome for deep learning models via GPU acceleration and a faster callback mechanism, which would result in faster execution of the model with lesser code and yield better precision in classifying the tissue slides. Residual Network (ResNet) is proven to handle the vanishing gradient and effective feature learning better. Integration of two computationally efficient technologies has yielded a precision accuracy with reasonable computational efforts. The proposed model has shown considerable efficiency in the evaluating parameters like sensitivity, specificity, accuracy, and F1 Score against the other dominantly used deep learning models. These insights have shown that the proposed approach might assist practitioners in analyzing Breast Cancer (BC) cases appropriately, perhaps saving future complications and death. Clinical and pathological analysis and predictive accuracy have been improved with digital image processing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acceleration
  • Breast Neoplasms* / diagnostic imaging
  • Carcinoma, Ductal, Breast*
  • Disease Progression
  • Female
  • Humans
  • Neoplasms, Second Primary*