TNF Receptors Choose HSC Fate in Supporting Dnmt3a-Mutant Clonal Hematopoiesis

Cancer Discov. 2022 Dec 2;12(12):2724-2726. doi: 10.1158/2159-8290.CD-22-1022.

Abstract

TNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential. See related article by SanMiguel et al., p. 2763 (3).

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Differentiation / genetics
  • Clonal Hematopoiesis*
  • Hematopoietic Stem Cells
  • Humans
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha*

Substances

  • Tumor Necrosis Factor-alpha
  • Receptors, Tumor Necrosis Factor