Abstract
TNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential. See related article by SanMiguel et al., p. 2763 (3).
©2022 American Association for Cancer Research.
Publication types
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Editorial
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Cell Differentiation / genetics
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Clonal Hematopoiesis*
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Hematopoietic Stem Cells
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Humans
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha*
Substances
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Tumor Necrosis Factor-alpha
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Receptors, Tumor Necrosis Factor