Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis

Anna Zaryczañska; Jolanta Gleñ; Monika Zabłotna; Roman J Nowicki; Magdalena Trzeciak

doi:10.5114/ada.2022.113130

Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis

Postepy Dermatol Alergol. 2022 Oct;39(5):959-964. doi: 10.5114/ada.2022.113130. Epub 2022 Mar 3.

Authors

Anna Zaryczañska¹, Jolanta Gleñ¹, Monika Zabłotna¹, Roman J Nowicki¹, Magdalena Trzeciak¹

Affiliation

¹ Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.

Abstract

Introduction: Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).

Aim: To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.

Material and methods: The study group consisted of 191 patients with AD and 168 controls.

Results: The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, p = 0.01).

Conclusions: The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.

Keywords: IL-33; atopic dermatitis; polymorphism.