Structural stabilization for a membrane structure under high-frequency vibration is still a recognized problem. In nature, honeybee wings with non-uniform material properties demonstrate excellent anti-interference ability. However, the correlation between the structural stabilization and mechanical properties of insect wings has not been completely verified. Here we demonstrate that the sclerotization diversity partially distinguishes the stiffness inhomogeneity of the wing structure. Furthermore, a wing cross-section model with diversity in elastic modulus is constructed to analyze the effect of stiffness distribution on stress optimization during flight. Our results demonstrate that the heterogeneous stiffness promotes the stress distribution and structural stabilization of the wing during flight, which may inspire more optimal designs for anisotropic high-strength membrane structures.