Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin

Thitinun Raknoo; Orawan Sae-Lim; Sutthiporn Pattharachayakul; Siripen Kanchanasuwan

doi:10.5415/apallergy.2022.12.e36

Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin

Asia Pac Allergy. 2022 Oct 17;12(4):e36. doi: 10.5415/apallergy.2022.12.e36. eCollection 2022 Oct.

Authors

Thitinun Raknoo¹, Orawan Sae-Lim², Sutthiporn Pattharachayakul², Siripen Kanchanasuwan³

Affiliations

¹ Pharmacy Department, Suratthani Hospital, Muang, Suratthani, Thailand.
² Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
³ Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Abstract

The aim of this study was to report the success of a clindamycin graded challenge. The patient was a 39-year-old human immunodeficiency virus-infected male with toxoplasmic encephalitis (TE) with a history of trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin allergy. He developed a reaction during TMP/SMX desensitization. Following the reaction, a graded challenge with clindamycin was performed in this study, and he became tolerant to clindamycin. No adverse drug reactions developed during the graded challenge. He successfully continued suppressive therapy with no further reactions or recurrences.

Keywords: AIDS patient; Clindamycin; Graded challenge; Toxoplasmic encephalitis.

Publication types

Case Reports