The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Pediatr Blood Cancer. 2023 May:70 Suppl 2:e30110. doi: 10.1002/pbc.30110. Epub 2022 Nov 30.

Abstract

This review highlights the role of several immunomodulating elements contributing to the tumor microenvironment of various pediatric renal tumors including Wilms tumor. The roles of innate and adaptive immune cells in renal tumors are summarized as well as immunomodulatory cytokines and other proteins. The expression and the predictive role of checkpoint modulators like PD-L1 and immunomodulating proteins like glypican-3, B7-H3, COX-2 are highlighted with a translational view toward potential therapeutic innovations. We further discuss the current state of preclinical models in advancing this field of study. Finally, examples of clinical trials of immunomodulating strategies such as monoclonal antibodies and chimeric antigen receptor T (CAR-T) cells for relapsed/refractory/progressive pediatric renal tumors are described.

Keywords: immunotherapy; pediatric renal tumor; tumor microenvironment.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • B7-H1 Antigen
  • Child
  • Humans
  • Immunomodulation
  • Kidney Neoplasms* / drug therapy
  • Tumor Microenvironment*

Substances

  • B7-H1 Antigen
  • Antibodies, Monoclonal