Surgical Treatment is Still Recommended for Patients Over 75 Years with IA NSCLC: A Predictive Model Based on Surveillance, Epidemiology and End Results Database

Wenting Zhang; Yafeng Liu; Jing Wu; Wenyang Wang; Jiawei Zhou; Jianqiang Guo; Qingsen Wang; Xin Zhang; Jun Xie; Yingru Xing; Dong Hu

doi:10.1177/10732748221142750

Surgical Treatment is Still Recommended for Patients Over 75 Years with IA NSCLC: A Predictive Model Based on Surveillance, Epidemiology and End Results Database

Cancer Control. 2022 Jan-Dec:29:10732748221142750. doi: 10.1177/10732748221142750.

Authors

Wenting Zhang¹, Yafeng Liu¹, Jing Wu^{1

2}, Wenyang Wang¹, Jiawei Zhou¹, Jianqiang Guo¹, Qingsen Wang¹, Xin Zhang¹, Jun Xie³, Yingru Xing^{1

3

4}, Dong Hu^{1

2

4

5}

Affiliations

¹ School of Medicine, 91594Anhui University of Science and Technology, Huainan, P.R. China.
² Anhui Province Engineering Laboratory of Occupational Health and Safety, 91594Anhui University of Science and Technology, Huainan, P.R. China.
³ 91594Cancer Hospital of Anhui University of Science and Technology, Huainan, P.R. China.
⁴ Department of Clinical Laboratory, Anhui Zhongke Gengjiu Hospital, Hefei, P.R. China.
⁵ Key Laboratory of Industrial Dust Prevention and Control & Occupational Safety and Health of the Ministry of Education, 91594Anhui University of Science and Technology, Huainan, P.R. China.

Abstract

Background: To determine the populations who suitable for surgical treatment in elderly patients (age ≥ 75 y) with IA stage.

Methods: The clinical data of NSCLC patients diagnosed from 2010 to 2015 were collected from the SEER database and divided into surgery group (SG) and no-surgery groups (NSG). The confounders were balanced and differences in survival were compared between groups using PSM (Propensity score matching, PSM). Cox regression analysis was used to screen the independent factors that affect the Cancer-specific survival (CSS). The surgery group was defined as the patients who surgery-benefit and surgery-no benefit according to the median CSS of the no-surgery group, and then randomly divided into training and validation groups. A surgical benefit prediction model was constructed in the training and validation group. Finally, the model is evaluated using a variety of methods.

Results: A total of 7297 patients were included. Before PSM (SG: n = 3630; NSG: n = 3665) and after PSM (SG: n = 1725, NSG: n = 1725) confirmed that the CSS of the surgery group was longer than the no-surgery group (before PSM: 82 vs. 31 months, P < .0001; after PSM: 55 vs. 39 months, P < .0001). Independent prognostic factors included age, gender, race, marrital, tumor grade, histology, and surgery. In the surgery cohort after PSM, 1005 patients (58.27%) who survived for more than 39 months were defined as surgery beneficiaries, and the 720 patients (41.73%) were defined surgery-no beneficiaries. The surgery group was divided into training group 1207 (70%) and validation group 518 (30%). Independent prognostic factors were used to construct a prediction model. In training group (AUC = .678) and validation group (AUC = .622). Calibration curve and decision curve prove that the model has better performance.

Conclusions: This predictive model can well identify elderly patients with stage IA NSCLC who would benefit from surgery, thus providing a basis for clinical treatment decisions.

Keywords: Non-small cell lung cancer; SEER database; nomogram; predictive model; surgery.

MeSH terms

Aged
Carcinoma, Non-Small-Cell Lung* / surgery
Databases, Factual
Humans
Lung Neoplasms* / surgery
Propensity Score