Sarcoidosis is a chronic granulomatous disorder affecting the lungs, skin, and many other organs. Twin studies suggest that genetic factors account, to a large degree, for the etiology of the disorder. Hence, theoretically, we could postulate that the phenomenon of superimposed mosaicism in the form of a pronounced segmental involvement, overlaying the disseminated non-segmental lesions, should also occur in sarcoidosis. Indeed, one case suggesting superimposed mosaicism in cutaneous sarcoidosis was found in the literature and is reassessed here.
Keywords: cutaneous sarcoidosis; flag-like pattern; polygenic disorder; segmental manifestation; superimposed mosaicism; twin studies.
© 2022 The Authors. American Journal of Medical Genetics Part A published by Wiley Periodicals LLC.