Vitamin B12 and Diabetic Foot: Α Mini-Review

Nikolaos D Karakousis; Elisavet E Pyrgioti; Petros N Georgakopoulos; Nikolaos Papanas

doi:10.1177/15347346221143018

Vitamin B₁₂ and Diabetic Foot: Α Mini-Review

Int J Low Extrem Wounds. 2022 Nov 29:15347346221143018. doi: 10.1177/15347346221143018. Online ahead of print.

Authors

Nikolaos D Karakousis¹, Elisavet E Pyrgioti², Petros N Georgakopoulos¹, Nikolaos Papanas³

Affiliations

¹ Primary Healthcare, Internal Medicine Department, Amarousion, Attica, Greece.
² Pharmacist, Private Practice, Athens, Greece.
³ Second Department of Internal Medicine, Diabetes Centre-Diabetic Foot Clinic, Democritus University of Thrace, Alexandroupolis, Greece.

PMID: 36448193
DOI: 10.1177/15347346221143018

Abstract

This narrative mini-review article aimed to investigate the potential association of vitamin B₁₂ levels with diabetic neuropathy (DN) and diabetic foot ulcers (DFUs). It was demonstrated that B₁₂ deficiency seems to be related to DFUs in cases of metformin administration and bariatric surgery. B₁₂ supplementation with dietary measures and agents may improve DN and quality of life (QoL). However, data are still preliminary and more experience is needed.

Keywords: B12 levels; diabetic foot; diabetic foot ulcers; diabetic neuropathy; type 2 diabetes mellitus.

Publication types

Review