Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics

Mingchen Yang; Somia Yassin Hussain Abdalkarim; Hou-Yong Yu; Rabie A M Asad; Dan Ge; Ying Zhou

doi:10.1016/j.carbpol.2022.120350

Thermo-sensitive composite microspheres incorporating cellulose nanocrystals for regulated drug release kinetics

Carbohydr Polym. 2023 Feb 1;301(Pt B):120350. doi: 10.1016/j.carbpol.2022.120350. Epub 2022 Nov 18.

Authors

Mingchen Yang¹, Somia Yassin Hussain Abdalkarim¹, Hou-Yong Yu², Rabie A M Asad³, Dan Ge¹, Ying Zhou⁴

Affiliations

¹ Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China.
² Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China.; Zhejiang Sci-Tech University Huzhou Research Institute Co., LTD, Huzhou 313000, China. Electronic address: phdyu@zstu.edu.cn.
³ Faculty of Industries Engineering and Technology, Department of Textile Engineering, University of Gezira, PO Box 20, Sudan.
⁴ Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China.. Electronic address: zhouying@zstu.edu.cn.

PMID: 36446510
DOI: 10.1016/j.carbpol.2022.120350

Abstract

Thermo-sensitive composite microspheres (TPCP) were developed to achieve the on-demand release of drugs. The TPCP microspheres were synthesized using Oil-in-Water (O/W) emulsion evaporation technique and then impregnated with thermo-sensitive polyethylene glycol (PEG). The addition of cellulose nanocrystals (CNCs) significantly enhance thermal stability, crystallization ability, and surface hydrophilicity of TPCP microspheres due to heterogeneous nucleation effect and hydrogen bonding interaction, resulting in stable microsphere structure. The thermal degradation temperature (T_max) increased by 13.8 °C, and the crystallinity improved by 20.9 % for 10 % TPCP. The thermo-sensitive composite microspheres showed the regulated cumulative release according to in vitro human physiological temperature changes. Besides, four release kinetics and possible release mechanism of TPCP microspheres were provided. Such thermo-responsive composite microspheres with control microsphere sizes and high encapsulation rate may have the potential to the development of on-demand and advanced controlled-release delivery systems.

Keywords: Cellulose nanocrystals; Composite microspheres; Drug release; Poly(3-hydroxybutyrate-co-3-hydroxyvalerate); Polyethylene glycol; Thermo-sensitive.

MeSH terms

Cellulose*
Drug Liberation
Humans
Kinetics
Microspheres
Nanoparticles*

Substances

Cellulose