Mathematical formalism of femtosecond laser-deoxyribonucleic acid interaction: thermal evolution

Mihai Oane; Bogdan A Sava; Muhammad Arif Mahmood; Natalia Mihailescu; Sinziana Anghel; Ana V Filip; Ion N Mihailescu; Cristian N Mihailescu; Carmen Ristoscu

doi:10.1016/j.heliyon.2022.e11765

Mathematical formalism of femtosecond laser-deoxyribonucleic acid interaction: thermal evolution

Heliyon. 2022 Nov 21;8(11):e11765. doi: 10.1016/j.heliyon.2022.e11765. eCollection 2022 Nov.

Authors

Affiliations

¹ National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania.
² University Politehnica of Bucharest, Bucharest, Romania.
³ Mechanical Engineering Program, Texas A&M University at Qatar, P.O. Box 23874, Doha, Qatar.
⁴ University of Bucharest, Faculty of Physics, RO-077125 Magurele, Ilfov, Romania.

Abstract

A novel analytical formalism is proposed based upon Quantum heat transport equation in order to describe the femtoseconds/picoseconds laser pulses interaction with the Deoxyribonucleic acid (DNA). The formalism generates solutions based upon inputs as: voltage, laser beam intensity and laser - DNA interaction time. Thermal waves induced inside irradiated DNA are defined and accounted for. Analytical simulations show that the optimum regime of laser - DNA interaction was reached for a potential carrier generated at the interface equal to 3.5 × 10^-3 eV. It has to be mentioned that the formalism breaks down if the potential carrier generated at the interface is inferior to 10^-2 eV. Accordingly, for pulse duration inferior to 1 ps, the laser beam spatial-temporal distribution has an essential role in defining the shape and magnitude of the thermal distribution within the irradiated DNA strands.

Keywords: Analytical simulation; DNA strands; Femtosecond laser irradiation; Quantum heat transport equation.