Muscle Sympathetic Excitatory Response to Dynamic 1-Leg Cycling in Heart Failure With Preserved Ejection Fraction

Mark B Badrov; Catherine F Notarius; Evan Keys; John S Floras

doi:10.1016/j.jaccas.2022.08.009

Muscle Sympathetic Excitatory Response to Dynamic 1-Leg Cycling in Heart Failure With Preserved Ejection Fraction

JACC Case Rep. 2022 Nov 16;4(22):1501-1503. doi: 10.1016/j.jaccas.2022.08.009.

Authors

Mark B Badrov¹, Catherine F Notarius¹, Evan Keys¹, John S Floras¹

Affiliation

¹ University Health Network and Sinai Health Division of Cardiology, Department of Medicine, University of Toronto and the Toronto General Hospital Research Institute, Toronto, Ontario, Canada.

Abstract

We provide the first description in a patient with heart failure with preserved ejection fraction of the "paradoxical," exaggerated reflex increase in muscle sympathetic nerve activity in the opposite, stationary limb during dynamic 1-leg cycling exercise that was documented previously in patients with reduced ejection fraction. (Level of Difficulty: Advanced.).

Keywords: BMI, body mass index; BP, blood pressure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction; MSNA, muscle sympathetic nerve activity; VO2peak, peak oxygen uptake; exercise; heart failure with preserved ejection fraction; sympathetic nerve activity.