Biomechanical properties analysis of forme fruste keratoconus and subclinical keratoconus

Abstract

Purpose: To analyze the biomechanical properties of the eye in patients with unilateral keratoconus with normal (forme fruste keratoconus [FFKC]) or abnormal topography (subclinical keratoconus [SKC]).

Methods: This study included 153 eyes of 153 participants, including 95 eyes of patients with unilateral keratoconus, and 58 eyes of 58 healthy controls. Contralateral eyes with unilateral keratoconus were divided into two groups according to clinical manifestations and global consensus: FFKC (n = 30) and SKC (n = 65). The biomechanical characteristics were analyzed using non-parametric tests; further analysis thereof was performed after adjusting for confounding factors (i.e., intraocular pressure, age, and corneal thickness). Receiver operating characteristic curve (ROC) was used to analyze the ability of the biomechanical parameters to distinguish FFKC from SKC.

Results: Statistically significant differences between the FFKC and SKC groups were found in 9 of the 18 corneal biomechanical parameters analyzed using non-parametric tests. After adjusting for confounding factors, the multivariate analysis still revealed significant statistical differences in A1-time (P = 0.017), integrated radius (IR) (P = 0.024), and tomographic and biomechanical index (TBI, P < 0.001) between the FFKC and SKC groups. Stiffness parameter at first applanation (SP-A1) (Area under ROC [AUROC] = 0.765) demonstrated the strongest distinguishing ability, except for TBI (AUROC = 0.858) and Corvis Biomechanical Index (AUROC = 0.849), however, there was no statistically significant difference in SP-A1 (P = 0.366) between FFKC and SKC.

Conclusions: Biomechanical parameters A1-time and IR have a high diversity between FFKC and SKC, besides TBI, and may reflect more subtle changes in corneal biomechanical properties (BPs) preceding SP-A1. The BPs of SKC are weaker than FFKC, which might be a basic and clue for the classification and diagnosis of the severity of early keratoconus in terms of biomechanics.

Keywords: Corneal biomechanics; Early keratoconus; Forme fruste keratoconus; Subclinical keratoconus; Unilateral keratoconus.