Application of amide proton transfer imaging for the diagnosis of neonatal hypoxic-ischemic encephalopathy

Sijin Chen; Xilong Liu; Jie Lin; Yingjie Mei; Kan Deng; Qiao Xue; Xiaoyan Song; Yikai Xu

doi:10.3389/fped.2022.996949

Application of amide proton transfer imaging for the diagnosis of neonatal hypoxic-ischemic encephalopathy

Front Pediatr. 2022 Nov 11:10:996949. doi: 10.3389/fped.2022.996949. eCollection 2022.

Authors

Sijin Chen^{1

2}, Xilong Liu¹, Jie Lin¹, Yingjie Mei³, Kan Deng⁴, Qiao Xue⁵, Xiaoyan Song⁶, Yikai Xu¹

Affiliations

¹ Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
² Department of Obstetrics & Gynecology, Nanfang Hospital Baiyun Branch, Southern Medical University, Guangzhou, China.
³ School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
⁴ C&TS MR Clinical Science, Philips Healthcare, Guangzhou, China.
⁵ Helong Street Community Health Service Center, Guangzhou, China.
⁶ Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Abstract

Objective: This study aimed to evaluate cerebral amide proton transfer signal intensity (SI) among controls, hypoxic-ischemic encephalopathy (HIE) neonates with normal conventional magnetic resonance imaging (HIE/MRI-) findings, and HIE neonates with abnormal conventional MRI (HIE/MRI+) findings.

Methods: Forty neonates diagnosed with neonatal HIE and sixteen normal neonates were evaluated. All neonates underwent conventional MRI scans and APT imaging. Cerebral APT SIs were compared to identify cerebral regions with significant APT changes among sixteen controls, thirteen HIE/MRI- patients, and twenty-seven HIE/MRI+ patients.

Results: Significantly increased APT SIs were observed in the HIE/MRI- group compared with controls, in the left insula, right occipital lobe, left cingulate gyrus (posterior part), and corpus callosum. Significantly increased APT SIs were found in the HIE/MRI+ group compared with controls, in the right anterior temporal lobe (medial part), anterior parts of the right parahippocampal and ambient gyri, left superior temporal gyrus (middle part), left insula, left cingulate gyrus (posterior part), and right lentiform nucleus. No significant APT SI differences were observed in the cerebellum and brainstem among the three groups.

Conclusion: Amide proton transfer imaging plays an important role in detecting hypoxic-ischemic encephalopathy regardless of conventional MRI findings. Changes in APT signal intensity may provide important insights into the characterization of the cerebral internal environment. This study suggests that APT imaging could be used as a complement to conventional MRI in the detection of hypoxic-ischemic encephalopathy in clinical practice.

Keywords: MRI; amide proton transfer; diagnosis; hypoxic–ischemic encephalopathy; neonate.