N-Methylfulleropyrrolidine-Based Multimode Sensor for Determination of Butoconazole Nitrate

Bianca-Maria Ţuchiu; Raluca-Ioana Stefan-van Staden; Jacobus Koos Frederick van Staden; Hassan Y Aboul-Enein

doi:10.1021/acsomega.2c05904

N-Methylfulleropyrrolidine-Based Multimode Sensor for Determination of Butoconazole Nitrate

ACS Omega. 2022 Nov 8;7(46):42537-42544. doi: 10.1021/acsomega.2c05904. eCollection 2022 Nov 22.

Authors

Bianca-Maria Ţuchiu^{1

2}, Raluca-Ioana Stefan-van Staden^{1

2}, Jacobus Koos Frederick van Staden¹, Hassan Y Aboul-Enein³

Affiliations

¹ Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021Bucharest-6, Romania.
² Faculty of Chemical Engineering and Biotechnologies, Politehnica University of Bucharest, 060042Bucharest, Romania.
³ Pharmaceutical and Medicinal Chemistry Department, the Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo12311, Egypt.

Abstract

A multimode sensor (a sensor responding simultaneously to more than one mode, e.g., stochastic mode, amperometric mode, voltammetric mode) based on graphite paste modified with N-methylfulleropyrrolidine was proposed for the determination of butoconazole nitrate in its pharmaceutical formulation. The stochastic mode and square wave voltammetry mode were applied for the determinations. Both the stochastic mode and square wave voltammetry mode were applied for a qualitative and quantitative assay of butoconazole nitrate. The sensor can be used between 1.68 × 10^-6 and 1.68 × 10⁴ μmol L^-1 when the stochastic mode is used and between 0.168 and 16.80 μmol L^-1 when the square wave voltammetry mode is used. The multimode sensor was reliably used for the determination of butoconazole nitrate in its pharmaceutical formulation, Gynofort cream, the recorded recoveries being higher than 99.00%, with RSD (%) values of lower than 2.00%.