The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Albert Sufianov; Aferin Beilerli; Sema Begliarzade; Tatiana Ilyasova; Valentin Kudriashov; Yanchao Liang; Ozal Beylerli

doi:10.1016/j.ncrna.2022.11.003

The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Noncoding RNA Res. 2022 Nov 14;8(1):89-95. doi: 10.1016/j.ncrna.2022.11.003. eCollection 2023 Mar.

Authors

Albert Sufianov^{1

2}, Aferin Beilerli³, Sema Begliarzade⁴, Tatiana Ilyasova⁵, Valentin Kudriashov⁶, Yanchao Liang⁷, Ozal Beylerli¹

Affiliations

¹ Educational and Scientific Institute of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
² Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
³ Department of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, Russia.
⁴ Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, Russia.
⁵ Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, Russia.
⁶ Gastric Cancer Center, West China Hospital of Sichuan University, China.
⁷ Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

Abstract

Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential closely affects alveolar bone repair and periodontal regeneration. Human periodontal ligament stem cells are pluripotent stem cells of mesenchymal origin, which can differentiate in osteoblasts and cementoblasts. However, the molecular mechanism of this differentiation activity is poorly studied. Noncoding RNAs (ncRNAs) belong to RNAs, which do not encode proteins and represent a large segment of the human transcriptome, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). It was shown that ncRNAs is involved in the proliferation and differentiation of cells, epigenetic modifications, apoptosis, as well as in complex control and pathogenesis of various diseases. NcRNAs are actively involved in the regulation of osteogenic genes in human periodontal ligament-derived cells. This article reviews the research progress of ncRNAs in the regulatory targets, pathways and functions of ncRNAs in the osteogenic differentiation of human periodontal ligament-derived cells.

Keywords: Circular RNA; Long non-coding RNA; Osteogenic differentiation; Periodontal ligament cell; Periodontal ligament stem cell; microRNA.

Publication types

Review