Sulfur-containing amino acids and their metabolites in atrial fibrosis

Rui Wang; Yong Fen Qi; Chun Hua Ding; Da Zhang

doi:10.3389/fphar.2022.1063241

Sulfur-containing amino acids and their metabolites in atrial fibrosis

Front Pharmacol. 2022 Nov 4:13:1063241. doi: 10.3389/fphar.2022.1063241. eCollection 2022.

Authors

Rui Wang^{1

2

3}, Yong Fen Qi^{1

2

3}, Chun Hua Ding^{4

5}, Da Zhang^{4

5}

Affiliations

¹ Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Beijing, China.
² Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, China.
³ Department of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
⁴ Cardiac Department, Aerospace Center Hospital, Beijing, China.
⁵ Peking University Aerospace School of Clinical Medicine, Beijing, China.

Abstract

Atrial fibrosis, a symbol of atrial structural remodelling, is a complex process involved in the occurrence and maintenance of atrial fibrillation (AF). Atrial fibrosis is regulated by multiple factors. Sulfur containing amino acids and their metabolites, such as hydrogen sulfide (H₂S) and taurine, can inhibit the process of atrial fibrosis and alleviate atrial remodeling. However, homocysteine can promote the activation of atrial fibroblasts and further promote atrial fibrosis. In this review, we will focus on the recent progress in atrial structural changes and molecular mechanisms of atrial fibrosis, as well as the regulatory roles and possible mechanisms of sulfur containing amino acids and their metabolites in atrial fibrosis. It is expected to provide new ideas for clarifying the mechanism of atrial fibrosis and finding targets to inhibit the progress of atrial fibrosis.

Keywords: atrial fibrosis; homocysteine; hydrogen sulfide; sulfur-containing amino acid; taurine.

Publication types

Review