Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects

Patrícia Botelho Silva; Darlene Godoy Oliveira; Amanda Douat Cardoso; Paulo Guirro Laurence; Paulo Sérgio Boggio; Elizeu Coutinho Macedo

doi:10.3389/fpsyg.2022.852219

Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects

Front Psychol. 2022 Nov 9:13:852219. doi: 10.3389/fpsyg.2022.852219. eCollection 2022.

Authors

Patrícia Botelho Silva¹, Darlene Godoy Oliveira¹, Amanda Douat Cardoso¹, Paulo Guirro Laurence¹, Paulo Sérgio Boggio¹, Elizeu Coutinho Macedo¹

Affiliation

¹ Social and Cognitive Neuroscience Laboratory, Developmental Disorders Program, Center for Health and Biological Sciences, Mackenzie Presbyterian University, São Paulo, Brazil.

Abstract

Developmental dyslexia is a specific learning disorder that presents cognitive and neurobiological impairments related to different patterns of brain activation throughout development, continuing in adulthood. Lexical decision tasks, together with electroencephalography (EEG) measures that have great temporal precision, allow the capture of cognitive processes during the task, and can assist in the understanding of altered brain activation processes in adult dyslexics. High-density EEG allows the use of temporal analyses through event-related potentials (ERPs). The aim of this study was to compare and measure the pattern of ERPs in adults with developmental dyslexia and good readers, and to characterize and compare reading patterns between groups. Twenty university adults diagnosed with developmental dyslexia and 23 healthy adult readers paired with dyslexics participated in the study. The groups were assessed in tests of intelligence, phonological awareness, reading, and writing, as well as through the lexical decision test (LDT). During LDT, ERPs were recorded using a 128-channel EEG device. The ERPs P100 occipital, N170 occipito-temporal, N400 centro-parietal, and LPC centro-parietal were analyzed. The results showed a different cognitive profile between the groups in the reading, phonological awareness, and writing tests but not in the intelligence test. In addition, the brain activation pattern of the ERPs was different between the groups in terms of hemispheric lateralization, with higher amplitude of N170 in the dyslexia group in the right hemisphere and opposite pattern in the control group and specificities in relation to the items of the LDT, as the N400 were more negative in the Dyslexia group for words, while in the control group, this ERP was more pronounced in the pseudowords. These results are important for understanding different brain patterns in developmental dyslexia and can better guide future interventions according to the changes found in the profile.

Keywords: cognitive profile; developmental dyslexia; electroencephalography; hemispheric lateralization; potentials related to events.