MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis

Se-Jin Kim; Elham Karamooz

doi:10.3390/ijms232214412

MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis

Int J Mol Sci. 2022 Nov 19;23(22):14412. doi: 10.3390/ijms232214412.

Authors

Se-Jin Kim^{1

2

3}, Elham Karamooz¹

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
² Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.
³ Medical Scientist Training Program, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.

Keywords: antigen presentation; immunology; mycobacteria.

Publication types

Review

MeSH terms

Antigen Presentation
Antigens
HLA-E Antigens
Histocompatibility Antigens Class I
Minor Histocompatibility Antigens / metabolism
Mycobacterium tuberculosis* / metabolism

Substances

Minor Histocompatibility Antigens
Histocompatibility Antigens Class I
Antigens

Abstract

Publication types

MeSH terms

Substances

Grants and funding